Vitamin B6 occurs in 3 forms–pyridoxine, pyridoxamine, and pyridoxal. B6 is absorbed within the large intestine. The muscle stores roughly 75-80 % of the vitamin even though the live stores approximately 5-10 %.
B6 is recommended for transaminations, ammonia release,, side chain cleavage reactions, dehydratases and decarboxylations. Its aldehyde group acts as a Schiff base to react with the amino groups of amino acids. meal prep delivery services acts to shuttle nitrogen between compounds.
Functions- The three forms of B6 can all be converted to the coenzyme PLP which aids in transamination & protein metabolism. PLP is essential for glycogen degradation; in addition, it helps with the development of the neurotransmitter, serotonin, the nonprotein portion of hemoglobin (heme), nucleic acids, and lecithin. Vitamin B6 is essential for the metabolism of tryptophan to niacin.
· Transaminations These reactions are necessary to recycle and also reuse nitrogen in the entire body. They’re the first stage in amino acid catabolism as well as the last stage in the synthesis of nonessential amino acids. Example: a-ketoglutarate + asparate glutamate + oxaloacetate
· Serine/ Threonine Deamination (Dehydratases) This response offers the production of the a keto acids of serine as well as threonine through oxidative removal of N as ammonia Example: Serine a-keto-serine + NH4+
· Decarboxylation These reactions often occur on the neuroactive amines of GABA., histamine, tyramine, and seratonin They are undoubtedly critical in porphyrin synthesis, intermediates within the synthesis of sphingomyelin, taurine and lecithin, as well as for the breakdown and desulfuration of cysteine.
· Glycogen Phosphorylase fifty % of all B6 inside the body is likely to glycogen phosphorylase however, the value is unknown. The response is important for recycling of folate and is as follows:
Serine glycine + 5,10-methylene-THF
Deficiency Deficiencies of vitamin B6 are relatively rare. People with a diet lacking in vitamin B6 will first show signs of weakness, irritability, insomnia, nervousness, and hydrated skin lesions. Far more advanced symptoms include growth failure, impaired motor function, hypochromic microcytic anemia, smooth tongue, along with convulsions.
The impaired motor function as well as other mental issues can be linked to a decrease in amino acid-based neurotransmitters (serotonin, tyramine, GABA, epinephrine). You see an increase in urea excretion because of a decline synthesis of nonessential amino acids. The nitrogen from these amino acids is not reprocessed by transamination and instead is excreted and also lost. You see an increase in urinary excretion especially inside the following amino acids: metabolites of glycine, methionine, and tryptophan. The hypochromic microcytic anemia is due to the fact that there’s a lowered synthesis of the B6 dependent porphyrin ring of hemoglobin.
Individuals who are at most risk would be the elderly with substandard vitamin intake, hemodialysis patients, alcoholics, and those that are on drug therapy. Overall, individuals with a high metabolic stress.
Sources Foods richest in vitamin B6 include:
o whole grains o legumes o nuts o navy beans o walnuts o meat (sirloin plus chicken) o fish (salmon plus shellfish) o bananas and apples o broccoli and spinach
Therapeutics Vitamin B6 may provide healing benefits for the second syndromes: carpal tunnel syndrome, glucose intolerance, sideroblastic anemia, neurologic disorders, hyperoxaluria, convulsive seizures, monosodium glutarate (MSG) intolerance, premenstral syndrome (Immune function and pms). Furthermore, vitamin B6 may well help decrease homocysteine levels and hence the chance of getting cardiovascular disease.